Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT<sub>1A</sub> receptor.
| Author | |
|---|---|
| Abstract |
:
Cannabinoid CB1 inverse agonists hold therapeutic promise as appetite suppressants but have produced suicidal behaviors among a small subpopulation in clinical trials. Anatomical and pharmacological evidence implicate the 5HT serotonin receptor in suicide in humans and impulsivity in humans and animals. |
| Year of Publication |
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2017
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| Journal |
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Psychopharmacology
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| Volume |
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234
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| Issue |
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6
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| Number of Pages |
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1029-1043
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| ISSN Number |
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0033-3158
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| URL |
:
https://doi.org/10.1007/s00213-017-4548-2
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| DOI |
:
10.1007/s00213-017-4548-2
|
| Short Title |
:
Psychopharmacology (Berl)
|
| Download citation |
